The ScotCRN provides expert support for both medicinal (CTIMP) and non-medicinal (Non-CTIMP)trials.
Please use the tabs below to access information about medicinal and non-medicinal studies currently being supported by the ScotCRN.
ScotCRN Active Medicinal Trials 2014-15 |
| ACCOUSTICS |
| A phase III, randomized, double–blind, placebo-controlled study to assess the efficacy, safety, and tolerability of Lebrikizumab in adolescent patients with uncontrolled asthma who are on inhaled corticosteroids and a second controller medication. |
| Specialty:. | Respiratory |
| Node: | Glasgow | PI: | James Paton |
| ADALUMIBAB |
| A randomised double blind placebo controlled study of the human anti-TNF monuclonal antibody adalumibab in paediatric ubjects with moderate to severe ulcerative colitis |
| Specialty:. | Gastroenterology |
| Node: | Glasgow | PI: | Richard Russel |
| ADHD Genetics |
| How do polymorphisms in the CES1 study affect how children with ADHD respond to Methylphenidate? |
| Specialty:. | Psychiatry |
| Node: | Dundee | PI: | David Coghill |
| ALX-0171 |
| Study of the effects of inhaled ALX-0171 in infants and toddlers with syncytial virus lower respiratory tract infection. |
| Specialty:. | Genetics/Metabolic |
| Node: | Edinburgh | PI: | Steve Cunningham |
| ALXN1101 |
| ALXN1101 in paediatric patients with MoCD Type A treated with rcPMP. |
| Specialty:. | Genetics/Metabolic |
| Node: | Glasgow | PI: | Bernd Schwahn |
| APPLES Astellas Pharma Europe |
| Study to assess long term safety of Tacrolimus ointment for treatment of atopic dermatitis. |
| Specialty:. | Dermatology |
| Node: | Dundee | PI: | Ross Hearn |
| Node: | PI: |
| DRAVET (Part A) |
| A double-blind, placebo-controlled, two-part study to investigate the dose-ranging safety and pharmacokinetics, followed by the efficacy and safety of cannabidiol (GWP42003-P) in children and young adults with Dravet Syndrome Dose finding arm of study. |
| Specialty:. | Neurology |
| Node: | Edinburgh | PI: |
| Node: | Glasgow | PI: | Sameer Zuberi |
| 30 March 2015 | Page 1 of 4 |
| DRAVET (Part B) |
| A double-blind, placebo-controlled, two-part study to investigate the dose-ranging safety and pharmacokinetics, followed by the efficacy and safety of cannabidiol (GWP42003-P) in children and young adults with Dravet Syndrome |
| Specialty:. | Neurology |
| Node: | Glasgow | PI: | Sameer Zuberi |
| DRI |
| A single blind study comparing the efficacy of Glycopyrronium and Hyoscine on drooling in children with neurodisabililty. |
| Specialty:. | Neurology |
| Node: | Edinburgh | PI: | Anne O’Hare |
| ESES |
| Corticosteroids or clobazam for ESES syndrome: a European, multicenter, randomized, controlled clinical trial |
| Specialty:. | Neurology |
| Node: | Glasgow | PI: |
| Node: | Edinburgh | PI: | Richard Chin |
| Evicel |
| A Prospective Randomized Controlled Study Evaluating the Safety and Efficacy of EVICEL® used for SutureLine Sealing in DuraMater Closure during Paediatric Neurosurgical Cranial Procedures |
| Specialty:. | Surgery |
| Node: | Edinburgh | PI: | Jothy Kandasamay |
| FOR-DMD |
| Duchenne Muscular Dystrophy: Double blind randomised trial to find optimum steroid regimen |
| Specialty:. | Genetics |
| Node: | Glasgow | PI: | Ian Horrocks |
| ICISS |
| International, multi centre, randomised parallel group, trial investigating the medical treatment of infantile spasms. |
| Specialty:. | Neurology |
| Node: | Dundee | PI: | Martin Kirkpatrick |
| Node: | Aberdeen | PI: | Ayaz Shah |
| Node: | Edinburgh | PI: | Alisa McLellan |
| KLIMB |
| A Phase 3, 2-arm, roll-over study to evaluate the long-term safety and pharmacodynamics of Ivacaftor treatment in paediatric subjects With CF and a CFTR gating mutation. |
| Specialty:. | Respiratory |
| Node: | Edinburgh | PI: | Jane Davis |
| 30 March 2015 | Page 2 of 4 |
| OAB |
| BOTOX in the treatment of urinary Incontinence in patients 12-17 Years of age |
| Specialty:. | Urology |
| Node: | Aberdeen | PI: | Christopher Driver |
| Phase 1 study in children with RSV |
| A randomized, double-blind, placebo-controlled, 2-part study of orally administered ALS-008176. |
| Specialty:. | Respiratory |
| Node: | Edinburgh | PI: | Steve Cunningham |
| PREDNOS |
| Long-term tapering versus standard prednisolone (steroid) therapy for the treatment of the initial episode of childhood nephrotic syndrome: national muliticentre randomised double blind trial. |
| Specialty:. | Nephrology |
| Node: | Edinburgh | PI: |
| Node: | Ayrshire and Arran | PI: | Bridget Oates |
| Node: | Glasgow | PI: |
| Node: | Aberdeen | PI: | Craig Oxley |
| PREDNOS 2 |
| Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome. |
| Specialty:. | Nephrology |
| Node: | Aberdeen | PI: |
| Node: | Ayrshire and Arran | PI: |
| Node: | Glasgow | PI: | Heather Maxwell |
| Node: | Edinburgh | PI: | David Hughes |
| SANAD II |
| A study of standard and new anti-epileptic drugs. |
| Specialty:. | Neurology |
| Node: | Edinburgh | PI: |
| Node: | Dundee | PI: | Martin Kirkpatrick |
| SNIFFLE 2 |
| Safety of Nasal Influenza Immunisation in Egg Allergic Children |
| Specialty:. | Immunology, allergy, |
| Node: | Edinburgh | PI: | Jurgen Schwarze |
| SYCAMORE |
| Randomised controlled trial of the effectiveness, safety, and cost effectiveness of adalimumab in combination with subcutaneous methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis. |
| Specialty:. | Rheumatology |
| Node: | Edinburgh | PI: | Brian Fleck |
| Node: | Aberdeen | PI: | Joyce Davidson |
| Node: | Glasgow | PI: | Janet Gardner-Medwin |
| TORPEDO-CF |
| Trial of optimal therapy for pseudomonas eradication in CF. |
| Specialty:. | Respiratory |
| Node: | Edinburgh | PI: | Steve Cunningham |
| Vertex 2 (KONTINUE) |
| A phase 3, 2-arm, roll-over study to evaluate the long-term safety and pharmacodynamics of Ivacaftor treatment in paediatric subjects With CF and a CFTR gating mutation. |
| Specialty:. | Respiratory |
| Node: | Edinburgh | PI: | Steve Cunningham |
| VOCALS |
| The effect of lebrikizumab in patients with severe asthma |
| Specialty:. | Respiratory |
| Node: | Glasgow | PI: | James Paton |
