The ScotCRN provides expert support for both medicinal (CTIMP) and non-medicinal (Non-CTIMP)trials.
Please use the tabs below to access information about medicinal and non-medicinal studies currently being supported by the ScotCRN.
ScotCRN Active Medicinal Trials 2014-15 |
ACCOUSTICS |
A phase III, randomized, double–blind, placebo-controlled study to assess the efficacy, safety, and tolerability of Lebrikizumab in adolescent patients with uncontrolled asthma who are on inhaled corticosteroids and a second controller medication. |
Specialty:. | Respiratory |
Node: | Glasgow | PI: | James Paton |
ADALUMIBAB |
A randomised double blind placebo controlled study of the human anti-TNF monuclonal antibody adalumibab in paediatric ubjects with moderate to severe ulcerative colitis |
Specialty:. | Gastroenterology |
Node: | Glasgow | PI: | Richard Russel |
ADHD Genetics |
How do polymorphisms in the CES1 study affect how children with ADHD respond to Methylphenidate? |
Specialty:. | Psychiatry |
Node: | Dundee | PI: | David Coghill |
ALX-0171 |
Study of the effects of inhaled ALX-0171 in infants and toddlers with syncytial virus lower respiratory tract infection. |
Specialty:. | Genetics/Metabolic |
Node: | Edinburgh | PI: | Steve Cunningham |
ALXN1101 |
ALXN1101 in paediatric patients with MoCD Type A treated with rcPMP. |
Specialty:. | Genetics/Metabolic |
Node: | Glasgow | PI: | Bernd Schwahn |
APPLES Astellas Pharma Europe |
Study to assess long term safety of Tacrolimus ointment for treatment of atopic dermatitis. |
Specialty:. | Dermatology |
Node: | Dundee | PI: | Ross Hearn |
Node: | PI: |
DRAVET (Part A) |
A double-blind, placebo-controlled, two-part study to investigate the dose-ranging safety and pharmacokinetics, followed by the efficacy and safety of cannabidiol (GWP42003-P) in children and young adults with Dravet Syndrome Dose finding arm of study. |
Specialty:. | Neurology |
Node: | Edinburgh | PI: |
Node: | Glasgow | PI: | Sameer Zuberi |
30 March 2015 | Page 1 of 4 |
DRAVET (Part B) |
A double-blind, placebo-controlled, two-part study to investigate the dose-ranging safety and pharmacokinetics, followed by the efficacy and safety of cannabidiol (GWP42003-P) in children and young adults with Dravet Syndrome |
Specialty:. | Neurology |
Node: | Glasgow | PI: | Sameer Zuberi |
DRI |
A single blind study comparing the efficacy of Glycopyrronium and Hyoscine on drooling in children with neurodisabililty. |
Specialty:. | Neurology |
Node: | Edinburgh | PI: | Anne O’Hare |
ESES |
Corticosteroids or clobazam for ESES syndrome: a European, multicenter, randomized, controlled clinical trial |
Specialty:. | Neurology |
Node: | Glasgow | PI: |
Node: | Edinburgh | PI: | Richard Chin |
Evicel |
A Prospective Randomized Controlled Study Evaluating the Safety and Efficacy of EVICEL® used for SutureLine Sealing in DuraMater Closure during Paediatric Neurosurgical Cranial Procedures |
Specialty:. | Surgery |
Node: | Edinburgh | PI: | Jothy Kandasamay |
FOR-DMD |
Duchenne Muscular Dystrophy: Double blind randomised trial to find optimum steroid regimen |
Specialty:. | Genetics |
Node: | Glasgow | PI: | Ian Horrocks |
ICISS |
International, multi centre, randomised parallel group, trial investigating the medical treatment of infantile spasms. |
Specialty:. | Neurology |
Node: | Dundee | PI: | Martin Kirkpatrick |
Node: | Aberdeen | PI: | Ayaz Shah |
Node: | Edinburgh | PI: | Alisa McLellan |
KLIMB |
A Phase 3, 2-arm, roll-over study to evaluate the long-term safety and pharmacodynamics of Ivacaftor treatment in paediatric subjects With CF and a CFTR gating mutation. |
Specialty:. | Respiratory |
Node: | Edinburgh | PI: | Jane Davis |
30 March 2015 | Page 2 of 4 |
OAB |
BOTOX in the treatment of urinary Incontinence in patients 12-17 Years of age |
Specialty:. | Urology |
Node: | Aberdeen | PI: | Christopher Driver |
Phase 1 study in children with RSV |
A randomized, double-blind, placebo-controlled, 2-part study of orally administered ALS-008176. |
Specialty:. | Respiratory |
Node: | Edinburgh | PI: | Steve Cunningham |
PREDNOS |
Long-term tapering versus standard prednisolone (steroid) therapy for the treatment of the initial episode of childhood nephrotic syndrome: national muliticentre randomised double blind trial. |
Specialty:. | Nephrology |
Node: | Edinburgh | PI: |
Node: | Ayrshire and Arran | PI: | Bridget Oates |
Node: | Glasgow | PI: |
Node: | Aberdeen | PI: | Craig Oxley |
PREDNOS 2 |
Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome. |
Specialty:. | Nephrology |
Node: | Aberdeen | PI: |
Node: | Ayrshire and Arran | PI: |
Node: | Glasgow | PI: | Heather Maxwell |
Node: | Edinburgh | PI: | David Hughes |
SANAD II |
A study of standard and new anti-epileptic drugs. |
Specialty:. | Neurology |
Node: | Edinburgh | PI: |
Node: | Dundee | PI: | Martin Kirkpatrick |
SNIFFLE 2 |
Safety of Nasal Influenza Immunisation in Egg Allergic Children |
Specialty:. | Immunology, allergy, |
Node: | Edinburgh | PI: | Jurgen Schwarze |
SYCAMORE |
Randomised controlled trial of the effectiveness, safety, and cost effectiveness of adalimumab in combination with subcutaneous methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis. |
Specialty:. | Rheumatology |
Node: | Edinburgh | PI: | Brian Fleck |
Node: | Aberdeen | PI: | Joyce Davidson |
Node: | Glasgow | PI: | Janet Gardner-Medwin |
TORPEDO-CF |
Trial of optimal therapy for pseudomonas eradication in CF. |
Specialty:. | Respiratory |
Node: | Edinburgh | PI: | Steve Cunningham |
Vertex 2 (KONTINUE) |
A phase 3, 2-arm, roll-over study to evaluate the long-term safety and pharmacodynamics of Ivacaftor treatment in paediatric subjects With CF and a CFTR gating mutation. |
Specialty:. | Respiratory |
Node: | Edinburgh | PI: | Steve Cunningham |
VOCALS |
The effect of lebrikizumab in patients with severe asthma |
Specialty:. | Respiratory |
Node: | Glasgow | PI: | James Paton |